Ci-dessous une sélection d’articles de recherche originaux issus des travaux de l’équipe, ainsi que la version pdf des articles disponibles librement. Contactez-nous si vous souhaitez obtenir un manuscrit.

Obstructive apneas in a mouse model of congenital central hypoventilation syndrome. Madani A, Pitollat G, Sizun E, Cardoit L, Ringot M, Bourgeois T, Ramanantsoa N, Delclaux C, Dauger S, d’Ortho MP, Thoby-Brisson M, Gallego J, Matrot B. Am J Respir Crit Care Med. 2021.

Nebulized curcumin protects neonatal lungs from antenatal insult in rats. Guillier C, Carrière D, Pansiot J, Maroni A, Billion E, Ringot M, Benoist JF, Jacques S, Matrot B, Jarreau PH, Vaiman D, Baud O, Zana-Taieb E. Am J Physiol Lung Cell Mol Physiol. 2021, Jun 23.

Cross-sectional case-control study of the relationships between pharyngeal compliance and heart rate variability indices in childhood obstructive sleep apnoea. Bokov P, Mauvais FX, Madani A, Matrot B, Lecendreux M, Delanoë C, Konofal E, Gallego J, Delclaux C. J Sleep Res. 2021 Apr 20;e13337.

Predictors of Suicidal Ideation and Preparatory Behaviors in Individuals With Bipolar Disorder: The Contribution of Chronobiological Dysrhythmicity and Its Association With Hopelessness. Palagini L, Miniati M, Caruso D, Cappelli A, Massa L, Pardini F, Petrucci A, Romeo F, Salarpi G, Etain B, Geoffroy PA. J Clin Psychiatry. 2021 Jan 19;82(2):20m13371.

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime. Leyrolle Q, Decoeur F, Briere G, Amadieu C, Quadros ARAA, Voytyuk I, Lacabanne C, Benmamar-Badel A, Bourel J, Aubert A, Sere A, Chain F, Schwendimann L, Matrot B, Bourgeois T, Grégoire S, Leblanc JG, De Moreno De Leblanc A, Langella P, Fernandes GR, Bretillon L, Joffre C, Uricaru R, Thebault P, Gressens P, Chatel JM, Layé S, Nadjar A. Neuropsychopharmacology. 2021 Feb;46(3):579-602.

Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection. Frija-Masson J, Debray MP, Gilbert M, Lescure FX, Travert F, Borie R, Khalil A, Crestani B, d’Ortho MP, Bancal C. Eur Respir J. 2020 Aug 6;56(2):2001754.

Sleep complaints are associated with increased suicide risk independently of psychiatric disorders: results from a national 3-year prospective study. Geoffroy PA, Oquendo MA, Courtet P, Blanco C, Olfson M, Peyre H, Lejoyeux M, Limosin F, Hoertel N. Mol Psychiatry. 2020 Apr 30.

Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome. Bokov P, Matrot B, Medjahdi N, Boureghda S, Essalhi M, Konofal E, Lecendreux M, Gallego J, Delclaux C. Sleep Med. 2020 May;69:172-178.

Breathing under Anesthesia: A Key Role for the Retrotrapezoid Nucleus Revealed by Conditional Phox2b Mutant Mice. Bourgeois T, Ringot M, Ramanantsoa N, Matrot B, Dauger S, Delclaux C, Gallego J. Anesthesiology. 2019 Jun;130(6):995-1006. Article en pdf

Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury. Rangon CM, Schang AL, Van Steenwinckel J, Schwendimann L, Lebon S, Fu T, Chen L, Beneton V, Journiac N, Young-Ten P, Bourgeois T, Maze J, Matrot B, Baburamani AA, Supramaniam V, Mallard C, Trottet L, Edwards AD, Hagberg H, Fleiss B, Li J, Chuang TT, Gressens P. Brain Behav Immun. 2018 Nov;74:265-276.

The utility of acoustic pharyngometry and rhinometry in pediatric obstructive sleep apnea syndrome. Bokov P, Essalhi M, Medjahdi N, Boureghda S, Konofal E, Lecendreux M, Delclaux C. Sleep Med. 2019 Jun;58:75-81.

Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice. Lecomte MJ, Bertolus C, Ramanantsoa N, Saurini F, Callebert J, Sénamaud-Beaufort C, Ringot M, Bourgeois T, Matrot B, Collet C, Nardelli J, Mallet J, Vodjdani G, Gallego J, Launay JM, Berrard S. Endocrinology. 2018 Apr 1;159(4):1844-1859.

Comparison of different methods of chemical loop gain measurement during tidal ventilation in awake healthy subjects. Bokov P, Matrot B, Gallego J, Delclaux C. J Appl Physiol (1985). 2018 Aug 23.

Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome. Vecchierini MF, Attali V, Collet JM, d’Ortho MP, Goutorbe F, Kerbrat JB, Leger D, Lavergne F, Monaca C, Monteyrol PJ, Morin L, Mullens E, Pigearias B, Martin F, Khemliche H, Lerousseau L, Meurice JC. Sleep Breath. 2018 Dec 22.

Analysis of the impact of corticosteroids adjuvant treatment during experimental invasive meningococcal infection in mice. Levy M, Deghmane AE, Aouiti-Trabelsi M, Dauger S, Faye A, Mariani-Kurkdjian P, Taha MK. Steroids. 2018 Aug;136:32-39.

Adaptive servo-ventilation for central sleep apnoea in systolic heart failure: results of the major substudy of SERVE-HF. Cowie MR, Woehrle H, Wegscheider K, Vettorazzi E, Lezius S, Koenig W, Weidemann F, Smith G, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H. Eur J Heart Fail. 2018 Mar;20(3):536-544.

Early Electroencephalography Findings in Cardiogenic Shock Patients Treated by Venoarterial Extracorporeal Membrane Oxygenation. Sinnah F, Dalloz MA, Magalhaes E, Wanono R, Neuville M, Smonig R, Radjou A, Mourvillier B, Bouadma L, Timsit JF, d’Ortho MP, Rouvel-Tallec A, Sonneville R.Crit Care Med. 2018 May;46(5):e389-e394.

Combination of obstructive sleep apnoea and insomnia treated by continuous positive airway pressure with the SensAwake pressure relief technology to assist sleep: a randomised cross-over trial protocol. Pepin JL, Gagnadoux F, Foote A, Vicars R, Ogra B, Viot-Blanc V, Benmerad M, D’Ortho MP, Tamisier R. BMJ Open. 2017 Oct 27;7(10):e015836.

Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis. Woehrle H, Cowie MR, Eulenburg C, Suling A, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H, Wegscheider K. Eur Respir J. 2017 Aug 31;50(2).

Bronchodilator Response Assessment of the Small Airways Obstructive Pattern. Bokov P, Martin C, Graba S, Gillet-Juvin K, Essalhi M, Delclaux C. Open Respir Med J. 2017 Jul 25;11:47-53.

A randomized controlled trial to validate the Alice PDX ambulatory device.
Nilius G, Domanski U, Schroeder M, Franke KJ, Hogrebe A, Margarit L, Stoica M, d’Ortho MP. Nat Sci Sleep. 2017 Jun 6;9:171-180.

Intravenous Immunoglobulin Therapy in Pediatric Narcolepsy: A Nonrandomized, Open-Label, Controlled, Longitudinal Observational Study. Lecendreux M, Berthier J, Corny J, Bourdon O, Dossier C, Delclaux C.  J Clin Sleep Med. 2017 Mar 15;13(3):441-453.

Pathophysiology of dyspnoea in acute pulmonary embolism: A cross-sectional evaluation. Sanchez O, Caumont-Prim A, Riant E, Plantier L, Dres M, Louis B, Collignon MA, Diebold B, Meyer G, Peiffer C, Delclaux C. Respirology. 2017 May;22(4):771-777.

Loop gain in severely obese women with obstructive sleep apnoea. Bokov P, Essalhi M, Delclaux C. Respir Physiol Neurobiol. 2016 Jan 15;221:49-53.

Increased volume of conducting airways in idiopathic pulmonary fibrosis is independent of disease severity: a volumetric capnography study. Plantier L, Debray MP, Estellat C, Flamant M, Roy C, Bancal C, Borie R, Israël-Biet D, Mal H, Crestani B, Delclaux C. J Breath Res. 2016 Feb 1;10(1):016005.

Wheezing recognition algorithm using recordings of respiratory sounds at the mouth in a pediatric population.  Bokov P, Mahut B, Flaud P, Delclaux C. Comput Biol Med. 2016 Mar 1;70:40-50.

Increased ventilatory variability and complexity in patients with hyperventilation disorder. Bokov P, Fiamma MN, Chevalier-Bidaud B, Chenivesse C, Straus C, Similowski T, Delclaux C.  J Appl Physiol (1985). 2016 May 15;120(10):1165-72.

Severe Central Sleep Apnea Associated With Chronic Baclofen Therapy: A Case Series. Olivier PY , Joyeux-Faure M, Gentina T , Launois SH, d’Ortho MP , Pépin JL, Gagnadoux F. Chest. 2016 May;149(5):e127-31.

Increased ventilatory variability and complexity in patients with hyperventilation disorder. Bokov P, Fiamma MN, Chevalier-Bidaud B, Chenivesse C, Straus C, Similowski T, Delclaux C. J Appl Physiol (1985). 2016 May 15;120(10):1165-72.

Safety study of Ciprofloxacin in juvenile mice. Bourgeois T, Delezoide AL, Zhao W, Guimiot F, Adle-Biassette H, Durand E, Ringot M, Gallego J, Storme T, Le Guellec C, Kassai B, Turner M, Jacqz-Aigrain E, Matrot B. Regul Toxicol Pharmacol 2016, 74:161-9. Article in pdf

Obstructive Sleep Apnoea Modulates Airway Inflammation and Remodelling in Severe Asthma. Taillé C, Rouvel-Tallec A, Stoica M, Danel C, Dehoux M, Marin-Esteban V, Pretolani M, Aubier M, d’Ortho MP.  PLoS One2016 Mar 2;11(3):e0150042.

A cross-over study of continuous tracheal cuff pressure monitoring in critically-ill children. Vottier G*, Matrot B*, Jones P, Dauger S.  Intensive Care Med. 2016 Jan;42(1):132-3.

Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H.  N Engl J Med. 2015 Sep 17;373(12):1095-105.

Protective effects of intermittent hypoxia on brain and memory in a mouse model of apnea of prematurity. Bouslama M, Adle-Biassette H, Ramanantsoa N, Bourgeois T, Bollen B, Brissaud O, Matrot B, Gressens P, Gallego J. Front Physiol 2015, in press. Article in pdf

Impact of inhaled nitric oxide on white matter damage in growth-restricted neonatal rats. Pham H, Duy AP, Pansiot J, Bollen B, Gallego J, Charriaut-Marlangue C, Baud O. Pediatr Res 2015, 77:563-9.

Airway cell involvement in intermittent hypoxia-induced airway inflammation. Philippe C, Boussadia Y, Prulière-Escabasse V, Papon JF, Clérici C, Isabey D, Coste A, Escudier E, d’Ortho MP. Sleep Breath. 2015 Mar;19(1):297-306.

Emotional disorders in adult mice heterozygous for the transcription factor Phox2b. Bollen B, Ramanantsoa N, Naert A, Matrot B, Van den Bergh O, D’Hooge R, Gallego J. Physiol Behavior 2015, 141:120-126.

Mortality in children with respiratory failure transported using high-frequency oscillatory ventilation. Jones P, Dauger S, Leger PL, Kessous K, Casadevall I, Maury I, Mazeron P, Lodé N.  Intensive Care Med. 2015 Jul;41(7):1363-4.

Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia. Charriaut-Marlangue C, Nguyen T , Bonnin P , Duy AP , Leger PL, Csaba Z, Pansiot J, Bourgeois T , Renolleau S, Baud O. Stroke. 2014 Mar;45(3):850-6.

Sleep continuity: a new metric to quantify disrupted hypnograms in non-sedated intensive care unit patients. Drouot X, Bridoux A, Thille AW, Roche-Campo F, Cordoba-Izquierdo A, Katsahian S, Brochard L, d’Ortho MP. Crit Care. 2014 Nov 25;18(6):628.

Inhaled NO prevents hyperoxia-induced white matter damage in neonatal rats. Pham H, Vottier G, Pansiot J, Duong-Quy S, Bollen B, Dalous J, Gallego J, Mercier JC, Dinh-Xuan AT, Bonnin P, Charriaut-Marlangue C, Baud O. Exp Neurol 2014, 252:114-23.

First dose in neonates: are juvenile mice, adults and in vitro-in silico data predictive of neonatal pharmacokinetics of fluconazole. Zhao W, Le Guellec C, Benjamin DK Jr, Hope WW, Bourgeois T, Watt KM, van den Anker JN, Matrot B, Manzoni P, Jacqz-Aigrain E. Clin Pharmacokinet 2014, 53:1005-18. Article in pdf

Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice. Lopez-Delisle L, Pierre-Eugène C, Bloch-Gallego E, Birling MC, Duband JL, Durand E, Bourgeois T, Matrot B, Sorg T, Huerre M, Meziane H, Roux MJ, Champy MF, Gallego J, Delattre O, Janoueix-Lerosey I. Oncotarget 2014, 5:2703-2713. Article in pdf

Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction. El-Khoury R, Dufour E, Rak M, Ramanantsoa N, Grandchamp N, Csaba Z, Duvillié B, Bénit P, Gallego J, Gressens P, Sarkis C, Jacobs HT, Rustin P. PLoS Genet 2013, 9:e1003182. Article in pdf

Arginine administration to critically ill patients with a low nitric oxide fraction in the airways: a pilot study. Tadié JM, Cynober L, Peigne V, Caumont-Prim A, Neveux N, Gey A, Guerot E, Diehl JL, Fagon JY, Tartour E, Delclaux C.  Intensive Care Med. 2013 Sep;39(9):1663-5.

Congenital central hypoventilation syndrome. Ramanantsoa N, Gallego J. Respir Physiol Neurobiol 2013, 189:272-279.

Bench to cribside: the path for developing a neuroprotectant. Ramanantsoa N, Fleiss B, Bouslama M, Matrot B, Schwendimann L, Cohen-Salmon C, Gressens P, Gallego J. Transl Stroke Res 2013, 4:258-277.

Inhaled NO protects cerebral white matter in neonatal rats with combined brain and lung injury. Pham H, Vottier G, Pansiot J, Dalous J, Gallego J, Gressens P, Duong-Quy S, Dinh-Xuan AT, Mercier JC, Biran V, Charriaut-Marlangue C, Baud O. Am J Respir Crit Care Med 2012, 185:897-899.

Genetic diseases: congenital central hypoventilation, Rett, and Prader-Willi syndromes. Gallego J. Compr Physiol 2012 2:2255-2279.

The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress. Miot S, Voituron N, Sterlin A, Vigneault E, Morel L, Matrot B, Ramanantsoa N, Amilhon B, Poirel O, Lepicard E, Mestikawy SE, Hilaire G, Gallego J. J Physiol (Lond) 2012, 590:5183-5198. Article in pdf

Olfactory classical conditioning in neonatal mouse pups using thermal stimuli. Bollen B, Matrot B, Ramanantsoa N, Van den Bergh O, D’Hooge R, Gallego J. Behav Brain Res 2012, 229:250-256.

Systemic inflammation disrupts the developmental program of white matter. Favrais G, van de Looij Y, Fleiss B, Ramanantsoa N, Bonnin P, Stoltenburg-Didinger G, Lacaud A, Saliba E, Dammann O, Gallego J, Sizonenko S, Hagberg H, Lelièvre V, Gressens P. Ann Neurol 2011, 70:550-565.

Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants. Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C. J Neuroscience 2011, 31:12880-12888. Article in pdf

Onset of Pup Locomotion Coincides with Loss of NR2C/D-mediated Cortico-striatal EPSCs and Dampening of Striatal Network Immature Activity. Dehorter N, Michel F, Marissal T, Rotrou Y, Matrot B, Lopez C, Humphries MD, Hammond C. Front Cell Neurosci 2011, 5:24-. Article in pdf

Impaired ventilatory and thermoregulatory responses to hypoxic stress in newborn phox2b heterozygous knock-out mice. Ramanantsoa N, Matrot B, Vardon G, Lajard AM, Voituron N, Dauger S, Denjean A, Hilaire G, Gallego J. Front Physiol 2011, 2:61. Article in pdf

Systemic inflammation disrupts the developmental program of white matter.  Favrais G, van de Looij Y, Fleiss B, Ramanantsoa N, Bonnin P, Stoltenburg-Didinger G, Lacaud A, Saliba E, Dammann O, Gallego J, Sizonenko S, Hagberg H, Lelièvre V, Gressens P. Annals of neurology 2011, 70:550-565.

Arousal Response to hypoxia in newborns : insights from animal models. Gallego J, Matrot B. Biol Psychol 2010, 84:39-45.

Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy. Michaud M1, Arnoux T, Bielli S, Durand E, Rotrou Y, Jablonka S, Robert F, Giraudon-Paoli M, Riessland M, Mattei MG, Andriambeloson E, Wirth B, Sendtner M, Gallego J, Pruss RM, Bordet T. Neurobiol Dis 2010, 38:125-35.

VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. Amilhon B, Lepicard E, Renoir T, Mongeau R, Popa D, Poirel O, Miot S, Gras C, Gardier AM, Gallego J, Hamon M, Lanfumey L, Gasnier B, Giros B, El Mestikawy S. J Neurosci 2010 Feb 10;30(6):2198-210. Article in pdf

Cold Stimulates the Behavioral Response to Hypoxia in Newborn Mice. Bollen B, Bouslama M, Matrot B, Rotrou Y, Vardon G, Lofaso F, Van den Bergh O, D’Hooge R, Gallego J. Am J Physiol Regul Integr Comp Physiol 2009, 296:R1503-R1511. Article in pdf

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models. Amiel J, Dubreuil V, Ramanantsoa N, Fortin G, Gallego ., Brunet JF Goridis C. Respir Physiol Neurobiol 2009, 168:125-132.

Different types of nutritional deficiencies affect different domains of spatial memory function checked in a radial arm maze. Ranade SC, Rose A, Rao, M, Gallego J, Gressens P, Mani S. Neuroscience 2008; 152:859-866.

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N. Proc Natl Acad Sci U S A 2008, 105:1710-1705. Article in pdf

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons. Dubreuil V, Ramanantsoa N, Trochet D, Vaubourg V, Amiel J, Gallego J, Brunet JF, Goridis C. Proc Natl Acad Sci U S A 2008; 105;1067-1072. Article in pdf